Dynamics of a two-receptor binding model: how affinities and capacities translate into long and short time behaviour and physiological corollaries

DOI10.3934/DCDSB.2012.17.2171zbMath1402.34052OpenAlexW2312815547MaRDI QIDQ449305

Lambertus A. Peletier, Willem De Winter, An Vermeulen

Publication date: 12 September 2012

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/dcdsb.2012.17.2171

zbMATH Keywords

systems pharmacology target-mediated drug disposition singular perturbation theory protein binding

Mathematics Subject Classification ID

Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Singular perturbations of ordinary differential equations (34D15) Qualitative investigation and simulation of ordinary differential equation models (34C60) Systems biology, networks (92C42)

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