Modeling Pharmacodynamics on HIV Latent Infection: Choice of Drugs is Key to Successful Cure via Early Therapy

DOI10.1137/16M1092003zbMath1377.34067MaRDI QIDQ4588165

Libin Rong, Naveen K. Vaidya

Publication date: 1 November 2017

Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)

zbMATH Keywords

periodic systempharmacodynamicsreproductive numberviral invasion thresholdHIV latent reservoirtime-varying drug effectiveness

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Qualitative investigation and simulation of ordinary differential equation models (34C60) Asymptotic properties of solutions to ordinary differential equations (34D05) Medical epidemiology (92C60)

Related Items (14)

Analysis of HIV latent infection model with multiple infection stages and different drug classes ⋮ Evolution dynamics of a time-delayed reaction-diffusion HIV latent infection model with two strains and periodic therapies ⋮ Modeling antiretrovial treatment to mitigate HIV in the brain: impact of the blood-brain barrier ⋮ Effects of periodic intake of drugs of abuse (morphine) on HIV dynamics: mathematical model and analysis ⋮ HIV infection dynamics and viral rebound: modeling results from humanized mice ⋮ HIV models with non‐exponential probability distributed infection progression ⋮ Modeling the effects of drugs of abuse on within-host dynamics of two HIV species ⋮ Time-varying pharmacodynamics in a simple non-integer HIV infection model ⋮ Modeling HIV dynamics under combination therapy with inducers and antibodies ⋮ Within-host viral dynamics in a multi-compartmental environment ⋮ Dynamics of a new HIV model with the activation status of infected cells ⋮ A diffusive virus model with a fixed intracellular delay and combined drug treatments ⋮ Resonance of periodic combination antiviral therapy and intracellular delays in virus model ⋮ Modelling the risk of HIV infection for drug abusers

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