Improving the Flexibility and Efficiency of Phase II Designs for Oncology Trials

DOI10.1111/j.1541-0420.2011.01720.xzbMath1271.62257OpenAlexW1992264597WikidataQ82854392 ScholiaQ82854392MaRDI QIDQ4649069

Stefan Englert, Meinhard Kieser

Publication date: 19 November 2012

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2011.01720.x

zbMATH Keywords

clinical trialstwo-stage designdiscrete dataadaptive designconditional error functionphase II

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Related Items (3)

Stopping for efficacy in single-arm phase II clinical trials ⋮ Single-arm phase II three-outcome designs with handling of over-running/under-running ⋮ Optimal adaptive two-stage designs for phase II cancer clinical trials

Cites Work

• Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches
• Designs for Group Sequential Phase II Clinical Trials
• Adaptive Two-Stage Designs for Single-Arm Phase IIA Cancer Clinical Trials
• One-Sample Multiple Testing Procedure for Phase II Clinical Trials
• Designed Extension of Studies Based on Conditional Power
• Modification of Sample Size in Group Sequential Clinical Trials
• Adaptive Sample Size Calculations in Group Sequential Trials
• Evaluation of Experiments with Adaptive Interim Analyses
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