Closed Testing Procedures for Group Sequential Clinical Trials with Multiple Endpoints

DOI10.1111/j.0006-341X.1999.01188.xzbMath1059.62722OpenAlexW1993632196WikidataQ73789919 ScholiaQ73789919MaRDI QIDQ4668329

Dei-In Tang, Nancy L. Geller

Publication date: 18 April 2005

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.1999.01188.x

zbMATH Keywords

early stoppingstep-down proceduresseveral treatments versus a controlstrong type I error control

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical analysis (62L10) Optimal stopping in statistics (62L15)

Related Items (21)

Interim evaluation of efficacy or futility in group‐sequential trials with multiple co‐primary endpoints ⋮ Sequential Bonferroni Methods for Multiple Hypothesis Testing with Strong Control of Family-Wise Error Rates I and II ⋮ Longitudinal clinical trials with adaptive choice of follow‐up time ⋮ Completeness and unbiased estimation of mean vector in the multivariate group sequential case ⋮ Allocating recycled significance levels in group sequential procedures for multiple endpoints ⋮ Unnamed Item ⋮ Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints ⋮ A unified framework for weighted parametric group sequential design ⋮ Step-up and step-down methods for testing multiple hypotheses in sequential experiments ⋮ Nonparametric directional testing for multivariate problems in conjunction with a closed testing principle ⋮ Adjusting O'Brien's Test to Control Type I Error for the Generalized Nonparametric Behrens–Fisher Problem ⋮ Confidence intervals for confirmatory adaptive two‐stage designs with treatment selection ⋮ Multistage Tests of Multiple Hypotheses ⋮ A Rejection Principle for Sequential Tests of Multiple Hypotheses Controlling Familywise Error Rates ⋮ Testing a Primary and a Secondary Endpoint in a Group Sequential Design ⋮ Monitoring Clinical Trials with Multiple Arms ⋮ Sequential Tests for Noninferiority and Superiority ⋮ Refined critical boundary with enhanced statistical power for non-directional two-sided tests in group sequential designs with multiple endpoints ⋮ Comparison of design strategies for a three-arm clinical trial with time-to-event endpoint: Power, time-to-analysis, and operational aspects ⋮ Basic concepts of group sequential and adaptive group sequential test procedures ⋮ A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks

Cites Work

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• A Simple Multivariate Test for One-Sided Alternatives
• Discrete Sequential Boundaries for Clinical Trials
• An approximate likelihood ratio test for a normal mean vector with nonnegative components with application to clinical trials
• On closed testing procedures with special reference to ordered analysis of variance
• Group Sequential Tests for Bivariate Response: Interim Analyses of Clinical Trials with Both Efficacy and Safety Endpoints
• A Group Sequential Procedure for All-Pairwise Comparisons of k Treatments Based on the Range Statistic
• An Approximate Likelihood Ratio Test for Comparing Several Treatments to a Control
• Global Tests for Multiple Binary Outcomes
• Monitoring Pairwise Comparisons in Multi-Armed Clinical Trials
• On The Design and Analysis of Randomized Clinical Trials with Multiple Endpoints

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