Group sequential crossover trial designs with strong control of the familywise error rate

DOI10.1080/07474946.2018.1466528zbMath1403.62200arXiv1710.03492OpenAlexW2963880075WikidataQ58587422 ScholiaQ58587422MaRDI QIDQ4689943

Michael J. Grayling, Adrian P. Mander, James M. S. Wason

Publication date: 22 October 2018

Published in: Sequential Analysis (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1710.03492

zbMATH Keywords

clinical trialfamilywise error ratecrossoverlinear mixed modelgroup sequential

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Generalized linear models (logistic models) (62J12) Sequential statistical design (62L05)

Uses Software

• Matlab
• R
• S-PLUS
• MEMSS

Cites Work

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• Group sequential designs for one-sided and two-sided hypothesis testing with provision for early stopping in favor of the null hypothesis
• A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection
• On Deriving the Inverse of a Sum of Matrices
• A group sequential approach to crossover trials for average bioequivalence
• Ethical considerations concerning treatment allocation in drug development trials

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