Patient-specific modeling of the neuroendocrine HPA-axis and its relation to depression: ultradian and circadian oscillations

DOI10.1016/J.MBS.2014.07.013zbMath1370.92072OpenAlexW2121598606WikidataQ48218470 ScholiaQ48218470MaRDI QIDQ472766

Stine Timmermann, Johanne Gudmand-Hoeyer, Johnny Tom Ottesen

Publication date: 20 November 2014

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2014.07.013

zbMATH Keywords

parameter estimationdepressionbio-markerHPA-axisnon-linear mixed effects ODE modelpatient specific

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biological rhythms and synchronization (92B25)

Related Items (4)

Patient specific modeling of the HPA axis related to clinical diagnosis of depression ⋮ A mathematical representation of the reactive scope model ⋮ Unnamed Item ⋮ Impulsive model of endocrine regulation with a local continuous feedback

Uses Software

• NONMEM

Cites Work

• Unnamed Item
• The minimal model of the hypothalamic-pituitary-adrenal axis
• Differential equations and their applications. An introduction to applied mathematics
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• A mathematical model of the hypothalamo-pituitary-adrenocortical system and its stability analysis
• Mathematical modeling of the hypothalamic -- pituitary -- adrenal system activity
• The Trace Ratio Optimization Problem
• STABILITY OF A GENERAL DELAY DIFFERENTIAL MODEL OF THE HYPOTHALAMO-PITUITARY-ADRENOCORTICAL SYSTEM
• Variability in the secretion of corticotropin-releasing hormone, adrenocorticotropic hormone and cortisol and understandability of the hypothalamic-pituitary-adrenal axis dynamics--a mathematical study based on clinical evidence
• A multivariate Markov chain model for categorical data sequences and its applications in demand predictions
• Finite mixture models

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