Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics

DOI10.1081/BIP-120019267zbMath1180.62182WikidataQ52017271 ScholiaQ52017271MaRDI QIDQ4803377

France Mentré, Sylvie Retout

Publication date: 2 April 2003

Published in: Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Statistical aspects of information-theoretic topics (62B10)

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Uses Software

• SAS

Cites Work

• Robust experiment design via stochastic approximation
• Design of cross-over trials for pharmacokinetic studies
• A simulated pseudo-maximum likelihood estimator for nonlinear mixed models.
• Laplace's approximation for nonlinear mixed models
• Optimal design in random-effects regression models
• MULTIPLE-OBJECTIVE DESIGNS IN A DOSE-RESPONSE EXPERIMENT
• Population Pharmacokinetic/Pharmacodynamic Methodology and Applications: A Bibliography