Protein evolution on partially correlated landscapes.
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Publication:4856913
DOI10.1073/pnas.92.21.9657zbMath0832.92014OpenAlexW2057239104WikidataQ33860729 ScholiaQ33860729MaRDI QIDQ4856913
Catherine A. Macken, Alan S. Perelson
Publication date: 16 January 1996
Published in: Proceedings of the National Academy of Sciences (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1073/pnas.92.21.9657
sequence spacespin glassessmoothnessfitness landscapesaffinity maturationexpected number of replacement mutationsprotein evolution on a rugged landscapesomatic hypermutation of antibody moleculesvariable degree of correlation
Related Items (18)
LOCALIZATION AND GLASSY DYNAMICS IN THE IMMUNE SYSTEM ⋮ Greedy adaptive walks on a correlated fitness landscape ⋮ Exact results for amplitude spectra of fitness landscapes ⋮ Universality classes of interaction structures for NK fitness landscapes ⋮ Combinatorial vector fields and the valley structure of fitness landscapes ⋮ Alphabet cardinality and adaptive evolution ⋮ Evolutionary accessibility in tunably rugged fitness landscapes ⋮ The \textit{nk} model and population genetics ⋮ Diversity against adversity: how adaptive immune system evolves potent antibodies ⋮ Analysis of adaptive walks on NK fitness landscapes with different interaction schemes ⋮ Global optima results for the Kauffman \(NK\) model ⋮ The peaks and geometry of fitness landscapes ⋮ Evolutionary accessibility of modular fitness landscapes ⋮ New global optima results for the Kauffman \(NK\) model: Handling dependency ⋮ Selecting among three basic fitness landscape models: additive, multiplicative and stickbreaking ⋮ Hierarchical distribution of ascending slopes, nearly neutral networks, highlands, and local optima at the \(d\)th order in an NK fitness landscape ⋮ Evolutionary dynamics of a polymorphic self-replicator population with a finite population size and hyper mutation rate ⋮ Distribution of the number of fitness maxima in Fisher’s geometric model
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