A minimal spatio-temporal model of the NF-\(\kappa \)B signalling pathway exhibits a range of behaviours

DOI10.1007/s11538-014-0011-2zbMath1330.92042OpenAlexW2167952957WikidataQ51041371 ScholiaQ51041371MaRDI QIDQ486608

Alan J. Terry

Publication date: 16 January 2015

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-014-0011-2

zbMATH Keywords

cancernegative feedbackgene regulatory networkspatio-temporal modelgenetic oscillatorNF-\(\kappa\)B

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37) Systems biology, networks (92C42)

Cites Work

• Models of genetic control by repression with time delays and spatial effects
• Interaction of spatial diffusion and delays in models of genetic control by repression
• Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
• A spatial model of cellular molecular trafficking including active transport along microtubules
• Spatio-temporal modelling of the NF-\(\kappa\)B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
• Genetic control models with diffusion and delays
• Mathematical model of NF-\( \kappa\)B regulatory module

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