Probabilistic Foundation of Confirmatory Adaptive Designs

DOI10.1080/01621459.2012.682540zbMath1261.62074OpenAlexW2040999143MaRDI QIDQ4916516

Peter Bauer, Georg Gutjahr, Werner Brannath

Publication date: 22 April 2013

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/01621459.2012.682540

zbMATH Keywords

conditional powercombination testssample size reassessmentconditional rejection probabilityconfirmatory clinical trialsconditional error functions

Mathematics Subject Classification ID

Linear inference, regression (62J99) Sequential statistical design (62L05)

Related Items (5)

SEAMLESS PHASE II/III CLINICAL TRIALS WITH COVARIATE ADAPTIVE RANDOMIZATION ⋮ Distribution theory following blinded and unblinded sample size re-estimation under parametric models ⋮ Adaptive dose‐response studies to establish proof‐of‐concept in learning‐phase clinical trials ⋮ Asymptotic properties of maximum likelihood estimators with sample size recalculation ⋮ Adaptive Multivariate Global Testing

Cites Work

• Unnamed Item
• A note on substitution in conditional distribution
• On design and inference for two-stage adaptive clinical trials with dependent data
• On Sample Size and Inference for Two‐Stage Adaptive Designs
• Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches
• An Approach to the Conditional Error Rate Principle with Nuisance Parameters
• Exact Confidence Bounds Following Adaptive Group Sequential Tests
• Designed Extension of Studies Based on Conditional Power
• Recursive Combination Tests
• A Unified Theory of Two-Stage Adaptive Designs
• Evaluation of Experiments with Adaptive Interim Analyses
• Substitution in Conditional Expectation
• Adaptive Design and Estimation in Randomized Clinical Trials with Correlated Observations

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