Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan

DOI10.1002/bimj.201200047zbMath1441.62524OpenAlexW1582360448WikidataQ43878310 ScholiaQ43878310MaRDI QIDQ4921947

Sue-Jane Wang, Mohammad F. Huque, Frank Bretz, Jason C. Hsu, Alexei Dmitrienko, Gary G. Koch, H. M. James Hung

Publication date: 28 May 2013

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201200047

zbMATH Keywords

correlationalpha propagationdecision path partition testDose-endpoint pairFisher's protected least significance differencemultiplicity-at-combined-trial level (or programwise type I error)parallel gatekeepingsingle hierarchical chaintruncated and regular hommel-based gatekeeping

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

Cites Work

• Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests
• Development of gatekeeping strategies in confirmatory clinical trials
• Testing for Efficacy in Primary and Secondary Endpoints by Partitioning Decision Paths
• Challenges to multiple testing in clinical trials
• Permutation Multiple Tests of Binary Features Do Not Uniformly Control Error Rates
• Approximation Theorems of Mathematical Statistics