Confidence intervals for confirmatory adaptive two‐stage designs with treatment selection
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Publication:4921948
DOI10.1002/bimj.201200053zbMath1441.62283OpenAlexW1524733818WikidataQ42268244 ScholiaQ42268244MaRDI QIDQ4921948
George Luta, Vladimir Dragalin, Ionut Bebu
Publication date: 28 May 2013
Published in: Biometrical Journal (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1002/bimj.201200053
adaptive designsconfidence intervalselection ruleadaptive seamless designconditional likelihood inference
Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)
Related Items (3)
Conditional Estimation in Two-Stage Adaptive Designs ⋮ Adjusting for selection bias in assessing treatment effect estimates from multiple subgroups ⋮ Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications
Uses Software
Cites Work
- Accurate parametric inference for small samples
- Drop-the-losers design: binomial case
- Two stage conditionally unbiased estimators of the selected mean
- Estimation following selection of the largest of two normal means
- Point estimates and confidence regions for sequential trials involving selection
- Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials
- Likelihood inference for a two-stage design with treatment selection
- Interval estimation for drop-the-losers designs
- Recursive Combination Tests
- Closed Testing Procedures for Group Sequential Clinical Trials with Multiple Endpoints
- Monitoring Pairwise Comparisons in Multi-Armed Clinical Trials
- Evaluation of Experiments with Adaptive Interim Analyses
- Phase 2 and 3 Combination Designs to Accelerate Drug Development
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