On the consistency of the continual reassessment method with multiple toxicity constraints

DOI10.1016/j.jspi.2015.03.001zbMath1322.62307OpenAlexW1969076593MaRDI QIDQ499432

Shing M. Lee, Bin Cheng

Publication date: 30 September 2015

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2015.03.001

zbMATH Keywords

consistencymodel misspecificationdose finding trialmultiplicative modelordinal toxicitysequential design

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

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Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
• Optimal Bayesian-feasible dose escalation for cancer phase I trials
• A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method
• Design and Analysis of Phase I Clinical Trials
• Continual reassessment method with multiple toxicity constraints
• Consistency of continual reassessment method under model misspecification
• Concavity of the Log Likelihood
• A Random Walk Rule for Phase I Clinical Trials
• Designs foe phase i cancer clinical trials with differentiation of graded toxicity
• The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach
• Dose-Finding Based on Multiple Toxicities in a Soft Tissue Sarcoma Trial