Patient-specific dose finding in seamless phase I/II clinical trials

DOI10.1080/07474946.2022.2105361OpenAlexW4295812909MaRDI QIDQ5043686

M. Iftakhar Alam, Shantonu Islam Shanto

Publication date: 6 October 2022

Published in: Sequential Analysis (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/07474946.2022.2105361

zbMATH Keywords

dose-finding studydose-response modelpatients' heterogeneityoptimum doseseamless phase I/II trial

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Design of statistical experiments (62K99) Sequential statistical design (62L05)

Cites Work

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• Individualized dosing for multiple ordered groups of patients
• Dose-Finding Designs for HIV Studies
• Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates
• Dose-Response Models with Covariates
• Simple benchmark for complex dose finding studies

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