Novel Bayesian Adaptive Designs and Their Applications in Cancer Clinical Trials
DOI10.1007/978-3-030-42196-0_17OpenAlexW3048473311MaRDI QIDQ5050425
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Publication date: 15 November 2022
Published in: Emerging Topics in Statistics and Biostatistics (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/978-3-030-42196-0_17
futilitydecision makingfrequentistefficiencyBayesian methodsimulationscalibrationstatistical inferenceclinical trialoptimal designDirichlet distributionimmunotherapyadaptive designposterior probabilitymultiple outcomesefficacymaximum tolerated dosephase I clinical trialcontinual reassessment methodearly stoppingtoxicityoperating characteristicsbiomarkeradaptive randomizationdose findinginterim analysissequential monitoringtime-to-event endpointphase II clinical trialdose escalationdose-limiting toxicityrandomized trialpredictive probabilityBayesian adaptive designbasket trialcancer trialbinary endpointBATTLE trialBayesian optimal intervalBOIN designBOP2 designGBM AGILE trialI-SPY2 trialmaster protocolmodel-assisted designmolecularly targeted agentmultinomial endpointplatform trialumbrella trial
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