Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: General Concepts

DOI10.1002/bimj.200510232zbMath1442.62289OpenAlexW2033969681WikidataQ36593604 ScholiaQ36593604MaRDI QIDQ5122851

Frank Bretz, Willi Maurer, Heinz Schmidli, Amy Racine, Franz König

Publication date: 24 September 2020

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.200510232

zbMATH Keywords

multiple testingadaptive testsclosure principlecombination testsadaptive seamless designhypotheses selection

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items (5)

SEAMLESS PHASE II/III CLINICAL TRIALS WITH COVARIATE ADAPTIVE RANDOMIZATION ⋮ Seamless phase II/III/IIIb clinical trial designs with different endpoints for different phases ⋮ Discussion on “Adaptive enrichment designs with a continuous biomarker” by N. Stallard ⋮ A hybrid geometric phase II/III clinical trial design based on treatment failure time and toxicity ⋮ Decision‐theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta‐binomial distribution

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