Unifying and Generalizing Methods for Removing Unwanted Variation Based on Negative Controls

DOI10.5705/ss.202018.0345zbMath1471.62504arXiv1705.08393OpenAlexW3098677849MaRDI QIDQ5155179

Matthew Stephens, David Gerard

Publication date: 6 October 2021

Published in: Statistica Sinica (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1705.08393

zbMATH Keywords

RNA-seqgene expressionunobserved confoundingnegative controlbatch effectunwanted variationcorrelated testhidden confounding

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Related Items (1)

Deterministic Parallel Analysis: An Improved Method for Selecting Factors and Principal Components

Uses Software

• FAMT
• leapp
• denoiseR
• missForest
• Eigenstrat
• ruv

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