Inference in Targeted Group‐Sequential Covariate‐Adjusted Randomized Clinical Trials

DOI10.1111/sjos.12013zbMath1349.62545OpenAlexW1952168951WikidataQ90906121 ScholiaQ90906121MaRDI QIDQ5413948

Mark J. Van der Laan, Antoine Chambaz

Publication date: 2 May 2014

Published in: Scandinavian Journal of Statistics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc6084807

zbMATH Keywords

robustnessasymptotic normalitycontiguityclinical trialadaptive designcanonical distributiongroup-sequential testingtargeted maximum likelihood methodology

Mathematics Subject Classification ID

Asymptotic properties of nonparametric inference (62G20) Nonparametric robustness (62G35) Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric estimation (62G05) Sequential statistical design (62L05) Sequential statistical analysis (62L10)

Related Items (4)

Nearly optimal truncated group sequential test on binomial proportions ⋮ Designing experiments toward shrinkage estimation ⋮ Refined critical boundary with enhanced statistical power for non-directional two-sided tests in group sequential designs with multiple endpoints ⋮ Toward Computerized Efficient Estimation in Infinite-Dimensional Models

Cites Work

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• A new family of covariate-adjusted response adaptive designs and their properties
• Sequential monitoring of response-adaptive randomized clinical trials
• Statistical monitoring of clinical trials. A unified approach.
• Asymptotic properties of covariate-adjusted response-adaptive designs
• Adaptive designs for normal responses with prognostic factors
• A theory for testing hypotheses under covariate-adaptive randomization
• The Theory of Response‐Adaptive Randomization in Clinical Trials

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