Designs for Phase I Clinical Trials with Multiple Courses of Subjects at Different Doses

DOI10.1111/J.1541-0420.2007.00772.XzbMath1146.62084OpenAlexW1968454182WikidataQ44916097 ScholiaQ44916097MaRDI QIDQ5434918

Shenghua Kelly Fan, You-Gan Wang

Publication date: 14 January 2008

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2007.00772.x

zbMATH Keywords

tablesFisher informationisotonic regressionestimation efficiencytoxicitydose finding

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric estimation (62G05) Reliability and life testing (62N05)

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Optimal Bayesian design applied to logistic regression experiments
• Continual Reassessment Method: A Likelihood Approach
• Bayesian Design for Dose-Response Curves with Penalized Risk
• Non-parametric optimal design in dose finding studies

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