Implementation of a Bayesian Design in a Dose‐Escalation Study of an Experimental Agent in Healthy Volunteers

DOI10.1111/j.1541-0420.2007.00841.xzbMath1132.62098OpenAlexW2016185902WikidataQ51911223 ScholiaQ51911223MaRDI QIDQ5450494

John Whitehead, Yinghui Zhou, Pasi Korhonen, Mika Mustonen

Publication date: 20 March 2008

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2007.00841.x

zbMATH Keywords

simulationphase I clinical trialBayesian decision proceduredose escalationhealthy volunteer study

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian problems; characterization of Bayes procedures (62C10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Related Items

Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials ⋮ Adaptive Bayesian compound designs for dose finding studies

Uses Software

• elicit-normlin

Cites Work

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• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Dose finding in drug development.
• Dose-Finding Designs for HIV Studies
• Statistical Methods for Dose‐Finding Experiments
• A New Dose‐Finding Design for Bivariate Outcomes
• A New Perspective on Priors for Generalized Linear Models
• Easy-to-implement Bayesian methods for dose-escalation studies in healthy volunteers
• Bayesian decision procedures based on logistic regression models for dose-finding studies