A Parallel Phase I/II Clinical Trial Design for Combination Therapies

DOI10.1111/j.1541-0420.2006.00685.xzbMath1137.62396OpenAlexW2006862074WikidataQ51908327 ScholiaQ51908327MaRDI QIDQ5459586

Jean-Pierre Issa, Xuelin Huang, Swati Biswas, Yasuhiro Oki, Donald A. Berry

Publication date: 29 April 2008

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2006.00685.x

zbMATH Keywords

logistic regressionefficacysynergytoxicitydose selection

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian inference (62F15) Medical applications (general) (92C50)

Related Items (5)

Semiparametric Dose Finding Methods for Partially Ordered Drug Combinations ⋮ Continual Reassessment Method for Partial Ordering ⋮ A Latent Contingency Table Approach to Dose Finding for Combinations of Two Agents ⋮ Bayesian phase I/II adaptively randomized oncology trials with combined drugs ⋮ A Three-Stage Bayesian Adaptive Phase I/II Design and Simulation Studies

Cites Work

• Bayesian statistics and the efficiency and ethics of clinical trials
• Seamlessly Expanding a Randomized Phase II Trial to Phase III
• Dose-Finding with Two Agents in Phase I Oncology Trials
• Design and Analysis of Phase I Clinical Trials
• Designs for Single- or Multiple-Agent Phase I Trials
• The Randomized Play-the-Winner Rule in Medical Trials
• Two‐Dimensional Dose Finding in Discrete Dose Space

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