A Correction for Ascertainment Bias in Estimating Rates of Onset of Highly Penetrant Genetic Disorders

DOI10.2143/AST.37.2.2024075zbMath1154.62082OpenAlexW4242668841MaRDI QIDQ5505910

Angus S. Macdonald, Carolina Espinosa

Publication date: 28 January 2009

Published in: ASTIN Bulletin (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.2143/ast.37.2.2024075

zbMATH Keywords

ascertainment biasNelson-Aalen estimaterate of onsetearly-onset Alzheimer's diseasePresenilin-1 gene

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric estimation (62G05) Censored data models (62N01) Medical applications (general) (92C50) Estimation in survival analysis and censored data (62N02)

Related Items (1)

Survival Analysis on Pedigrees: A Marked Point Process Model

Cites Work

• A resolution of the ascertainment sampling problem. I: Theory
• A Nelson-Aalen Estimate of the Incidence Rates of Early-Onset Alzheimer's Disease Associated with the Presenilin-1 Gene
• Statistical models based on counting processes

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