Retrospective Analysis of Sequential Dose‐Finding Designs

DOI10.1111/J.1541-0420.2005.00353.XzbMath1079.62119OpenAlexW2112811160WikidataQ51965193 ScholiaQ51965193MaRDI QIDQ5717156

John O'Quigley

Publication date: 12 January 2006

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2005.00353.x

zbMATH Keywords

maximum likelihoodclinical trialdose-finding studiesmaximum tolerated dosecontinual reassessment methodtoxicitydose escalationphase 1 trial

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05) Estimation in survival analysis and censored data (62N02)

Related Items (1)

Adaptive clinical trial designs for phase I cancer studies

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• A stochastic Newton-Raphson method
• Design and Analysis of Phase I Clinical Trials
• Efficient Sequential Designs With Binary Data
• Consistency of continual reassessment method under model misspecification
• Estimation Following a Sequentially Designed Experiment
• Miscellanea. A stopping rule for the continual reassessment method
• Continual Reassessment Method: A Likelihood Approach
• Bayesian decision procedures based on logistic regression models for dose-finding studies

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