Nonparametric sequential testing in clinical trials with incomplete multivariate observations

DOI10.1093/BIOMET/78.1.123zbMath0717.62068OpenAlexW2024446781MaRDI QIDQ5748769

D. Y. Lin

Publication date: 1991

Published in: Biometrika (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1093/biomet/78.1.123

zbMATH Keywords

martingalelocal alternativesAIDSrandomized clinical trialsasymptotic powerinterim analysismultiple endpointsasymptotic joint distributionrepeated significance testingoverall significance levelStopping boundariestime-to-event variablesweighted sum of the linear rank statistics

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical analysis (62L10)

Related Items (6)

Analyzing multiple end points with a two-stage design in clinical trials ⋮ Completeness and unbiased estimation of mean vector in the multivariate group sequential case ⋮ Advances in medical statistics arising from the AIDS epidemic ⋮ Nonparametric Rank‐Based Methods for Group Sequential Monitoring of Paired Censored Survival Data ⋮ An Adaptive Approach to Implementing Bivariate Group Sequential Clinical Trial Designs ⋮ Group-sequential logrank methods for trial designs using bivariate non-competing event-time outcomes

Uses Software

• AS 195

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