RECEPTOR-MEDIATED ENDOCYTOSIS MODELING OF ANTIBODY-DRUG CONJUGATES TO THE RELEASED PAYLOAD WITHIN THE INTRACELLULAR SPACE CONSIDERING TARGET ANTIGEN EXPRESSION LEVELS

DOI10.11948/20190232zbMath1460.92094OpenAlexW3112821712MaRDI QIDQ5858080

Il Hyo Jung, Anna Park, Jong Hyuk Byun

Publication date: 9 April 2021

Published in: Journal of Applied Analysis & Computation (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.11948/20190232

zbMATH Keywords

drug deliveryreceptor-mediated endocytosisADC mathematical modelantibody-drug conjugates (ADCs)bystander-Killing effecttarget antigen expression level

Mathematics Subject Classification ID

Medical applications (general) (92C50) Mathematical modeling or simulation for problems pertaining to biology (92-10)

Cites Work

• A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback
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