Bias induced by adaptive dose-finding designs

DOI10.1080/02664763.2019.1649375OpenAlexW2964989159MaRDI QIDQ5861424

Nancy Flournoy, Assaf P. Oron

Publication date: 1 March 2022

Published in: Journal of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/02664763.2019.1649375

zbMATH Keywords

up-and-down proceduresinterval designscontinual reassessment methodBernoulli regression analysisinference following stochastic processesphase i clinical trials

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

Related Items (4)

A modified Huber loss function for continual reassessment methods in clinical trials ⋮ A general framework for the analysis of adaptive experiments ⋮ Efficiency of observed information adaptive designs in linear models ⋮ Editorial to special issue V WCDANM 2018

Cites Work

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• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• When does the expectation of a ratio equal the ratio of expectations?
• Asymptotic normality of maximum likelihood estimators from multiparameter response-driven designs
• Cumulative cohort design for dose-finding
• BIAS CALCULATIONS FOR ADAPTIVE URN DESIGNS
• On estimating binomial response relations
• Approximate bias calculations for sequentially designed experiments
• A Unified Theory of Two-Stage Adaptive Designs
• Bias reduction of maximum likelihood estimates
• Asymptotically Optimal Response‐Adaptive Designs for Allocating the Best Treatment: An Overview
• Asymptotic Properties of the Block Up-and-Down Method in Bio-assay
• On stopping times and stochastic monotonicity
• A Method for Obtaining and Analyzing Sensitivity Data

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