Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies

DOI10.1080/01621459.2021.1914634zbMath1506.62445OpenAlexW3152499279MaRDI QIDQ5881063

Unnamed Author, Joel Schwartz, Xihong Lin, Zhong-Hua Liu, Andrea Baccarelli, Jincheng Shen

Publication date: 9 March 2023

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/01621459.2021.1914634

zbMATH Keywords

hypothesis testingindirect effectscausal mediation analysiscomposite nulldivide-aggregate composite-null testgenome-wide epigenetic studiesmediation effectsproportions of true nulls

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Hypothesis testing in multivariate analysis (62H15) Paired and multiple comparisons; multiple testing (62J15)

Related Items (5)

GMEPS: a fast and efficient likelihood approach for genome-wide mediation analysis under extreme phenotype sequencing ⋮ A Simultaneous Likelihood Test for Joint Mediation Effects of Multiple Mediators ⋮ Mediation analysis method review of high throughput data ⋮ Replicability across multiple studies ⋮ Detecting multiple replicating signals using adaptive filtering procedures

Uses Software

• SPSS
• mediation
• SAS
• HIMA

Cites Work

• Adjusting batch effects in microarray expression data using empirical Bayes methods
• An unexpected encounter with Cauchy and Lévy
• Conceptual issues concerning mediation, interventions and composition
• Identification, inference and sensitivity analysis for causal mediation effects
• A stochastic process approach to false discovery control.
• Genome-wide analyses of sparse mediation effects under composite null hypotheses
• Empirical Bayes Analysis of a Microarray Experiment
• Asymptotic Statistics
• A Direct Approach to False Discovery Rates
• Correlated z-Values and the Accuracy of Large-Scale Statistical Estimates
• Estimating the Null and the Proportion of Nonnull Effects in Large-Scale Multiple Comparisons
• Large-Scale Simultaneous Hypothesis Testing
• All of Nonparametric Statistics

This page was built for publication: Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies