Waiting times to appearance and dominance of advantageous mutants: Estimation based on the likelihood

DOI10.1016/S0025-5564(00)00064-XzbMath1004.92030OpenAlexW1993432880WikidataQ43548521 ScholiaQ43548521MaRDI QIDQ5936131

Thomas B. Kepler, Michael D. Radmacher

Publication date: 16 February 2003

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/s0025-5564(00)00064-x

zbMATH Keywords

germinal center reactionkey mutationmaximum-likelihood estimatessomatic hypermutationstochastic selection

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Problems related to evolution (92D15) Physiology (general) (92C30)

Uses Software

• bootstrap

Cites Work

• Assessing the accuracy of the maximum likelihood estimator: Observed versus expected Fisher information
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