Cross-over trials in drug development: Theory and practice

DOI10.1016/S0378-3758(00)00318-9zbMath0976.62106MaRDI QIDQ5939490

Stephen Senn

Publication date: 26 September 2001

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

zbMATH Keywords

bioequivalencepharmacokineticscarry-overclinical trialcross-over trialsmulti-period designspharmacodynamics

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items (6)

The performance of a two-stage analysis of ABAB/BABA crossover trials ⋮ Notes on estimation of the proportion ratio in the presence of carryover effects under the AB/BA crossover trial ⋮ Robust assessment of two-treatment higher-order cross-over designs against missing values ⋮ Cross-over trials in drug development: Theory and practice ⋮ Circular First- and Second-Order Balanced Repeated Measurements Designs ⋮ A nonparametric procedure for the analysis of balanced crossover designs

Cites Work

• Unnamed Item
• Modelling and optimality in the design of crossover studies for medical applications
• An unbiased test for the bioequivalence problem
• Bioequivalence trials, intersection-union tests and equivalence confidence sets. With comments and a rejoinder by the authors
• A new procedure for testing equivalence in comparative bioavailability and other clinical trials
• The Crossover Experiment for Clinical Trials
• Symmetrical Confidence Intervals for Bioequivalence Trials
• Estimating treatment effects in clinical crossover trials
• On optimal tests for general interval-hypotheses
• Use of Two-Stage Test Statistic in the Two-Period Crossover Trials
• THE PROBABLE ERROR OF A MEAN
• Cross-over trials in drug development: Theory and practice

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