An iterative method to protect the type I error rate in bioequivalence studies under two‐stage adaptive 2×2 crossover designs

DOI10.1002/BIMJ.201900388zbMath1523.62169OpenAlexW3091202292WikidataQ100404411 ScholiaQ100404411MaRDI QIDQ6067315

Unnamed Author, Unnamed Author, Unnamed Author, Jordi Ocanã, Helmut Schütz

Publication date: 16 November 2023

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201900388

zbMATH Keywords

average bioequivalence (ABE)generic drug productsignificance level adjustmenttwo-stage adaptive designs (TSD)type I error control (T1E)

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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