Adaptive dose‐response studies to establish proof‐of‐concept in learning‐phase clinical trials

DOI10.1002/BIMJ.202100044zbMath1523.62162arXiv2102.10434OpenAlexW3202019112MaRDI QIDQ6068332

Unnamed Author, Michael P. McDermott

Publication date: 15 December 2023

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/2102.10434

zbMATH Keywords

adaptive designsproof-of-conceptconditional rejection probability principlegeneralized multiple contrast testsMCP-Mod

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Unnamed Item
• Response-adaptive dose-finding under model uncertainty
• Combining dependent \(P\)-values.
• Group Sequential and Confirmatory Adaptive Designs in Clinical Trials
• Adaptive dose-finding: Proof of concept with type I error control
• Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches
• Recursive Combination Tests
• Evaluation of Experiments with Adaptive Interim Analyses
• Probabilistic Foundation of Confirmatory Adaptive Designs
• Conditional Rejection Probabilities of Student'st-test and Design Adaptations
• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies

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