gBOIN‐ET: The generalized Bayesian optimal interval design for optimal dose‐finding accounting for ordinal graded efficacy and toxicity in early clinical trials

DOI10.1002/bimj.202100263zbMath1523.62217MaRDI QIDQ6068828

Masataka Taguri, Kentaro Takeda, Satoshi Morita

Publication date: 15 December 2023

Published in: Biometrical Journal (Search for Journal in Brave)

zbMATH Keywords

model-assisted designBayesian adaptive dose-finding designefficacy gradephase I-II clinical trial designtoxicity grade

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Dose-Finding Based on Efficacy-Toxicity Trade-Offs
• Pseudo Maximum Likelihood Methods: Theory
• The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach
• Dose-Finding Based on Multiple Toxicities in a Soft Tissue Sarcoma Trial
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