Optimal dose‐finding for efficacy–safety models

DOI10.1002/bimj.202000181zbMath1523.62221OpenAlexW3151307666MaRDI QIDQ6070996

Unnamed Author, Frank Miller

Publication date: 27 November 2023

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.202000181

zbMATH Keywords

optimal designdose-findingsequential designbivariate modelElfving's method

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items

Robust optimal designs using a model misspecification term

Cites Work

• Unnamed Item
• Optimal design for prediction in multiresponse linear models based on rectangular confidence region
• Computing optimal designs of multiresponse experiments reduces to second-order cone program\-ming
• Elfving's theorem for \(D\)-optimality
• A geometric characterization of \(c\)-optimal designs for heteroscedastic regression
• On optimal designs for clinical trials: an updated review
• Geometry of \(E\)-optimality
• Dose finding in drug development.
• Optimal designs for a multiresponse Emax model and efficient parameter estimation
• Optimal Designs for Dose-Finding Studies
• Adaptive Dc-optimal designs for dose finding based on a continuous efficacy endpoint
• Sequential Designs for Binary Data with the Purpose to Maximize the Probability of Response
• On c-optimal design measures
• MULTIPLE-OBJECTIVE DESIGNS IN A DOSE-RESPONSE EXPERIMENT
• Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials
• Optimal Design of Experiments
• Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes
• Optimum Allocation in Linear Regression Theory