Modelling how increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant may affect the efficacy and synergy of TMPRSS2 and Cathepsin B/L inhibitors

DOI10.1016/J.JTBI.2023.111568zbMath1521.92040OpenAlexW4382753519MaRDI QIDQ6078351

Pranesh Padmanabhan, Narendra M. Dixit

Publication date: 27 September 2023

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2023.111568

zbMATH Keywords

mathematical modellingviral kineticsCOVID-19SARS-CoV-2spike proteindrug synergyOmicronCathepsinTMPRSS2

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32)

Cites Work

• Multiple cohort study of hospitalized SARS-CoV-2 in-host infection dynamics: parameter estimates, identifiability, sensitivity and the eclipse phase profile

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