Monotonicity conditions for avoiding counterintuitive decisions in basket trials

DOI10.1002/BIMJ.202100287zbMath1523.62088MaRDI QIDQ6089920

Unnamed Author, Meinhard Kieser, Unnamed Author

Publication date: 15 December 2023

Published in: Biometrical Journal (Search for Journal in Brave)

zbMATH Keywords

Bayesian statisticsclinical trial designbasket trialinformation borrowing

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• A Bayesian basket trial design that borrows information across strata based on the similarity between the posterior distributions of the response probability
• Divergence measures based on the Shannon entropy
• Power gains by using external information in clinical trials are typically not possible when requiring strict type I error control

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