Neuronal Resilience and Calcium Signaling Pathways in the Context of Synapse Loss and Calcium Leaks: A Computational Modeling Study and Implications for Alzheimer’s Disease
DOI10.1137/23M1557842zbMath1530.92037OpenAlexW4389339930MaRDI QIDQ6139400
Unnamed Author, Unnamed Author, Gillian Queisser, Unnamed Author
Publication date: 18 December 2023
Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1137/23m1557842
numerical analysisAlzheimer's diseaseamyloid-betamultiscale modelingsynapse losselectro-calcium model
Neural networks for/in biological studies, artificial life and related topics (92B20) Computational methods for problems pertaining to biology (92-08) Pathology, pathophysiology (92C32)
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- The progression towards Alzheimer's disease described as a bistable switch arising from the positive loop between amyloids and \(\mathrm{Ca}^{2+}\)
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