Single-arm phase II three-outcome designs with handling of over-running/under-running

DOI10.1080/24754269.2023.2189348OpenAlexW4382361363MaRDI QIDQ6178382

Jianan Hui, Bob Zhong, Wenchuan Guo

Publication date: 18 January 2024

Published in: Statistical Theory and Related Fields (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/24754269.2023.2189348

zbMATH Keywords

optimal designsphase II trialsalpha spendingasymmetric alphago/no-go/inconclusive outcomesover-running and under-runningtwo-stage and three-stage designs

Mathematics Subject Classification ID

Statistics (62-XX)

Cites Work

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• Designed Extension of Studies Based on Conditional Power
• Improving the Flexibility and Efficiency of Phase II Designs for Oncology Trials
• Optimal inference for Simon's two-stage design with over or under enrollment at the second stage
• A sample size adjustment procedure for clinical trials based on conditional power

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