A modified Huber loss function for continual reassessment methods in clinical trials

DOI10.1080/07474946.2023.2276154OpenAlexW4390604205MaRDI QIDQ6186404

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Publication date: 2 February 2024

Published in: Sequential Analysis (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/07474946.2023.2276154

zbMATH Keywords

clinical trialsmaximum tolerated dosephase I trialsBayesian adaptive designscontinual reassessment methodsmodified Huber loss functiontoxicity interval loss function

Mathematics Subject Classification ID

Theory of statistical experiments (62B15) Optimal statistical designs (62K05) Point estimation (62F10) Bayesian inference (62F15) Bayesian problems; characterization of Bayes procedures (62C10) Empirical decision procedures; empirical Bayes procedures (62C12) Sequential estimation (62L12)

Cites Work

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• Sequential analysis. Tests and confidence intervals
• Design and Analysis of Phase I Clinical Trials
• Stationarity and Convergence of the Metropolis-Hastings Algorithm: Insights into Theoretical Aspects
• Robust Estimation of a Location Parameter
• On the Theory of Dynamic Programming
• Bias induced by adaptive dose-finding designs

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