Macrophage phenotype transitions in a stochastic gene-regulatory network model

DOI10.1016/j.jtbi.2023.111634OpenAlexW4387641596MaRDI QIDQ6192798

Susanna Röblitz, Hwayeon Ryu, Anna-Simone Josefine Frank, Kamila Larripa

Publication date: 13 February 2024

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2023.111634

zbMATH Keywords

transition path theorycellular signalingMarkov state modeling

Mathematics Subject Classification ID

Cell biology (92C37) Systems biology, networks (92C42)

Cites Work

• Fuzzy spectral clustering by PCCA+: application to Markov state models and data classification
• Extending transition path theory: periodically driven and finite-time dynamics
• Mathematical investigation of innate immune responses to lung cancer: the role of macrophages with mixed phenotypes
• Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making
• Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization
• Transition Path Theory for Markov Jump Processes
• Large Sample Properties of Simulations Using Latin Hypercube Sampling
• Constructing the equilibrium ensemble of folding pathways from short off-equilibrium simulations

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