Operator Splitting for Adaptive Radiation Therapy with Nonlinear Health Dynamics

DOI10.1080/10556788.2022.2078824zbMath1509.90155arXiv2105.01286WikidataQ114099382 ScholiaQ114099382MaRDI QIDQ6366763

Publication date: 4 May 2021

Abstract: We present an optimization-based approach to radiation treatment planning over time. Our approach formulates treatment planning as an optimal control problem with nonlinear patient health dynamics derived from the standard linear-quadratic cell survival model. As the formulation is nonconvex, we propose a method for obtaining an approximate solution by solving a sequence of convex optimization problems. This method is fast, efficient, and robust to model error, adapting readily to changes in the patient's health between treatment sessions. Moreover, we show that it can be combined with the operator splitting method ADMM to produce an algorithm that is highly scalable and can handle large clinical cases. We introduce an open-source Python implementation of our algorithm, AdaRad, and demonstrate its performance on several examples.

Mathematics Subject Classification ID

Large-scale problems in mathematical programming (90C06) Applications of mathematical programming (90C90) Nonconvex programming, global optimization (90C26) Medical applications (general) (92C50)

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