Diversity against adversity: how adaptive immune system evolves potent antibodies

DOI10.1007/S10955-011-0241-8zbMath1226.82035OpenAlexW2004531833MaRDI QIDQ639322

Konstantin B. Zeldovich, Muyoung Heo, Eugene I. Shakhnovich

Publication date: 20 September 2011

Published in: Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10955-011-0241-8

zbMATH Keywords

somatic hypermutationimmune responsegerminal centersB cellsDarwinian evolutionadaptive immunitysequence diversity

Mathematics Subject Classification ID

Problems related to evolution (92D15) Interacting particle systems in time-dependent statistical mechanics (82C22) Protein sequences, DNA sequences (92D20) Cell biology (92C37)

Cites Work

• Dynamics of one-pass germinal center models: implications for affinity maturation
• An analysis of B cell selection mechanisms in germinal centers
• Protein evolution on partially correlated landscapes.
• Modeling and optimization of populations subject to time-dependent mutation.

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