Flexible model-based non-negative matrix factorization with application to mutational signatures

DOI10.1515/sagmb-2023-0034zbMATH Open1537.92027MaRDI QIDQ6544880

Ragnhild Laursen, Asger Hobolth, Lasse Maretty

Publication date: 27 May 2024

Published in: Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

zbMATH Keywords

Poisson regressionnon-negative matrix factorization (NMF)cancer genomicsexpectation-maximization (EM) algorithminteraction termsmutational signatures

Mathematics Subject Classification ID

Protein sequences, DNA sequences (92D20) Pathology, pathophysiology (92C32)

Cites Work

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• Choosing starting values for the EM algorithm for getting the highest likelihood in multivariate Gaussian mixture models
• A Sampling Algorithm to Compute the Set of Feasible Solutions for NonNegative Matrix Factorization with an Arbitrary Rank

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