Numerical modeling of senile plaque development under conditions of limited diffusivity of amyloid-\(\beta\) monomers

DOI10.1016/J.JTBI.2024.111823zbMATH Open1541.92034MaRDI QIDQ6554184

A. V. Kuznetsov

Publication date: 12 June 2024

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

zbMATH Keywords

mathematical modelingneurodegenerative diseaseFinke-Watzky modelneurotoxicity

Mathematics Subject Classification ID

Neural biology (92C20) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Numerical methods for partial differential equations, initial value and time-dependent initial-boundary value problems (65M99) Pathology, pathophysiology (92C32)

Cites Work

• An analytical solution simulating growth of Lewy bodies

Related Items (1)

The growth rate of senile plaques is determined by the competition between the rate of deposition of free A\(\beta\) aggregates into plaques and the autocatalytic production of free A\(\beta\) aggregates

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