Gain of function mutation in K(ATP) channels and resulting upregulation of coupling conductance are partners in crime in the impairment of \(\mathrm{Ca}^{2+}\) oscillations in pancreatic \(\beta\)-cells

DOI10.1016/J.MBS.2024.109224zbMATH Open1542.92031MaRDI QIDQ6594599

Elanur Aydin Karatas, Omer Faruk Karatas, Vehpi Yildirim, Richard Bertram, Cigdem Yalcin, Ozel Capik, Murat An, Mesut Akyuz

Publication date: 28 August 2024

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

gene expression\(\beta\)-cellspancreatic isletsdiabetescomputational modelinggap junctions\(\mathrm{Ca}^{2+}\) imaging

Mathematics Subject Classification ID

Cell biology (92C37) Computational methods for problems pertaining to biology (92-08) Pathology, pathophysiology (92C32)

Cites Work

• A calcium-based phantom bursting model for pancreatic islets
• Topological and phenomenological classification of bursting oscillations
• Simulating, Analyzing, and Animating Dynamical Systems
• Deconstructing the integrated oscillator model for pancreatic \(\beta \)-cells

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