CRM and partial order CRM with adaptive rescaling for dose-finding in immunotherapy trials with a continuous outcome

DOI10.1002/sim.9729zbMATH Open1545.62535MaRDI QIDQ6625779

Jason P. Fine, Pooja T. Saha, Anastasia Ivanova

Publication date: 28 October 2024

Published in: Statistics in Medicine (Search for Journal in Brave)

zbMATH Keywords

partial orderquasi-likelihoodcontinual reassessment methodphase 1 clinical trials

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Title not available (Why is that?)
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• A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints
• The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach
• Consistency of the when the curve is not monotone and its application to the POCRM
• Change-point joint model for identification of plateau of activity in early phase trials
• Phase I clinical trials in adoptive T-cell therapies

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