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Conditional power and friends: the why and how of (un)planned, unblinded sample size recalculations in confirmatory trials

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Publication:6626742
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DOI10.1002/sim.9288zbMATH Open1547.62312MaRDI QIDQ6626742

Kaspar Rufibach, Kevin Kunzmann, Michael J. Grayling, James Wason, David S. Robertson, Kim May Lee

Publication date: 29 October 2024

Published in: Statistics in Medicine (Search for Journal in Brave)




zbMATH Keywords

optimal designadaptive designconditional powerpredictive powerinterim analysissample size recalculation


Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)



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A two-stage group-sequential design for delayed treatment responses with the possibility of trial restart






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