Improving safety of the continual reassessment method via a modified allocation rule

DOI10.1002/sim.8450zbMATH Open1546.62552MaRDI QIDQ6627502

Pavel Mozgunov, Thomas Jaki

Publication date: 29 October 2024

Published in: Statistics in Medicine (Search for Journal in Brave)

zbMATH Keywords

loss functionphase I clinical trialrestricted parameter spacecontinual reassessment methodallocation rule

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• The treatment versus experimentation dilemma in dose finding studies
• Dose finding with escalation with overdose control (EWOC) in cancer clinical trials
• Operating characteristics of the standard phase I clinical trial design.
• Compositional data: the sample space and its structure
• Continual Reassessment Method for Partial Ordering
• Continual Reassessment Method: A Likelihood Approach
• Loss functions in restricted parameter spaces and their Bayesian applications
• Non-parametric optimal design in dose finding studies
• On criteria for measures of compositional difference

Related Items (1)

Practical implementation of the partial ordering continual reassessment method in a phase I combination-schedule dose-finding trial

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