On the properties of the toxicity index and its statistical efficiency

DOI10.1002/sim.8858zbMATH Open1546.62616MaRDI QIDQ6627682

Arash A. Amini, Greg Yothers, Zahra S. Razaee, André Rogatko, Márcio Augusto Diniz, Mourad Tighiouart

Publication date: 29 October 2024

Published in: Statistics in Medicine (Search for Journal in Brave)

zbMATH Keywords

adverse eventstwo-sample testPoisson-limit modelT-rank preservationtoxicity index

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Escalation with overdose control using ordinal toxicity grades for cancer phase I clinical trials
• Asymptotic Statistics
• Designs foe phase i cancer clinical trials with differentiation of graded toxicity
• The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach
• Dose-Finding Based on Multiple Toxicities in a Soft Tissue Sarcoma Trial

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