On optimal biomarker cutoffs accounting for misclassification costs in diagnostic trilemmas with applications to pancreatic cancer

DOI10.1002/sim.9432zbMATH Open1547.62134MaRDI QIDQ6628659

John V. Tsimikas, Leonidas E. Bantis

Publication date: 29 October 2024

Published in: Statistics in Medicine (Search for Journal in Brave)

zbMATH Keywords

prevalencekernel density estimatorsmonotone likelihood ratiocostsROC surfaceBox-CoxYouden3-class classificationfalse class rates

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

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• Estimation of the diagnostic threshold accounting for decision costs and sampling uncertainty
• Youden Index and Associated Cut-Points for Three Ordinal Diagnostic Groups
• Construction of confidence regions in the ROC space after the estimation of the optimal Youden index‐based cut‐off point
• Estimation of the Youden Index and its Associated Cutoff Point
• Comparing the Areas Under Two Correlated ROC Curves: Parametric and Non‐Parametric Approaches
• Distribution of the Anderson-Darling Statistic

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