Misinterpretation risks of global stochastic optimisation of kinetic models revealed by multiple optimisation runs

DOI10.1016/j.mbs.2018.11.002zbMath1409.92107OpenAlexW2900042377WikidataQ58585370 ScholiaQ58585370MaRDI QIDQ669142

Sven Sahle, Egils Stalidzans, Katrina Landmane, Jurijs Sulins

Publication date: 20 March 2019

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2018.11.002

zbMATH Keywords

metabolic engineeringoptimisationcopasihomeostatic constraintparallel optimisation runs

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Systems biology, networks (92C42)

Uses Software

• sbtoolbox
• COPASI
• BioModels
• ConvAn
• SpaceScanner
• PottersWheel

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